麦角酸二乙胺（LSD）增强反转学习：大脑5-羟色胺水平同时升高。
Reversal learning enhanced by lysergic acid diethylamide (LSD): concomitant rise in brain 5-hydroxytryptamine levels.
作者信息
King A R, Martin I L, Melville K A
出版信息
Br J Pharmacol. 1974 Nov;52(3):419-26. doi: 10.1111/j.1476-5381.1974.tb08611.x.
Abstract
1 Small doses of lysergic acid diethylamide (LSD) (12.5-50 mug/kg) consistently facilitated learning of a brightness discrimination reversal.2 2-Bromo-lysergic acid diethylamide (BOL-148), a structural analogue of LSD, with similar peripheral anti-5-hydroxytrypamine activity but no psychotomimetic properties, had no effect in this learning situation at a similar dose (25 mug/kg).3 LSD, but not BOL-148, caused a small but significant increase in brain 5-hydroxytryptamine levels, but had no effect on the levels of catecholamines in the brain at 25 mug/kg.
摘要
小剂量的麦角酸二乙酰胺（LSD）（12.5 - 50微克/千克）持续促进亮度辨别反转学习。
2-溴麦角酸二乙酰胺（BOL - 148）是LSD的结构类似物，具有相似的外周抗5-羟色胺活性，但无拟精神病特性，在相似剂量（25微克/千克）下对这种学习情况没有影响。
LSD而非BOL - 148导致脑5-羟色胺水平小幅但显著升高，但在25微克/千克时对脑中儿茶酚胺水平没有影响。
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