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线粒体3-羟基-3-甲基戊二酰辅酶A合酶基因表达的调控。其在酮体生成控制中的作用。

Regulation of the expression of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene. Its role in the control of ketogenesis.

作者信息

Casals N, Roca N, Guerrero M, Gil-Gómez G, Ayté J, Ciudad C J, Hegardt F G

机构信息

Unidad de Bioquímica, Facultad de Farmacia, Universidad de Barcelona, Spain.

出版信息

Biochem J. 1992 Apr 1;283 ( Pt 1)(Pt 1):261-4. doi: 10.1042/bj2830261.

DOI:10.1042/bj2830261
PMID:1348927
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1131023/
Abstract

We have explored the role of mitochondrial 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase in regulating ketogenesis. We had previously cloned the cDNA for mitochondrial HMG-CoA synthase and have now studied the regulation in vivo of the expression of this gene in rat liver. The amount of processed mitochondrial HMG-CoA synthase mRNA is rapidly changed in response to cyclic AMP, insulin, dexamethasone and refeeding, and is greatly increased by starvation, fat feeding and diabetes. We conclude that one point of ketogenic control is exercised at the level of genetic expression of mitochondrial HMG-CoA synthase.

摘要

我们探究了线粒体3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）合酶在调节生酮作用中的作用。我们之前已克隆了线粒体HMG-CoA合酶的cDNA，现在研究了该基因在大鼠肝脏中表达的体内调节情况。加工后的线粒体HMG-CoA合酶mRNA的量会因环磷酸腺苷、胰岛素、地塞米松和再喂养而迅速变化，并且在饥饿、高脂喂养和糖尿病状态下会大幅增加。我们得出结论，生酮控制的一个关键点在于线粒体HMG-CoA合酶的基因表达水平。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef8c/1131023/64acbb6df007/biochemj00138-0261-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef8c/1131023/fd3b52ae3e58/biochemj00138-0260-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef8c/1131023/64acbb6df007/biochemj00138-0261-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef8c/1131023/fd3b52ae3e58/biochemj00138-0260-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef8c/1131023/64acbb6df007/biochemj00138-0261-a.jpg

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