与柳氮磺胺吡啶治疗溃疡性结肠炎相关的肺部浸润和嗜酸性粒细胞增多症：一例报告及文献复习

Pulmonary infiltration and eosinophilia associated with sulfasalazine therapy for ulcerative colitis: a case report and review of literature.

作者信息

Yamakado S, Yoshida Y, Yamada T, Kishida T, Kobayashi M, Nomura T

机构信息

Third Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.

出版信息

Intern Med. 1992 Jan;31(1):108-13. doi: 10.2169/internalmedicine.31.108.

DOI:10.2169/internalmedicine.31.108

PMID:1348965

Abstract

We report a 52-yr-old man with ulcerative colitis who developed sulfasalazine-induced pulmonary infiltration with eosinophilia (PIE syndrome), which resolved completely after withdrawal of this drug. Desensitization to sulfasalazine was successful, and allowed the patient to receive this drug without recurrence of the pulmonary toxicity. This is the first case of the sulfasalazine-induced PIE syndrome in Japan; a review of the world literature found no previous cases of successful desensitization following sulfasalazine-induced PIE syndrome.

摘要

我们报告了一名52岁患有溃疡性结肠炎的男性，他出现了柳氮磺胺吡啶诱发的伴有嗜酸性粒细胞增多的肺部浸润（PIE综合征），在停用该药物后完全缓解。对柳氮磺胺吡啶脱敏成功，使患者能够继续使用该药物而无肺部毒性复发。这是日本首例柳氮磺胺吡啶诱发的PIE综合征；对世界文献的回顾未发现此前有柳氮磺胺吡啶诱发的PIE综合征后脱敏成功的病例。