与柳氮磺胺吡啶相关的肺部浸润和嗜酸性粒细胞增多。

Pulmonary infiltrates and eosinophilia associated with sulfasalazine.

作者信息

Wang K K, Bowyer B A, Fleming C R, Schroeder K W

出版信息

Mayo Clin Proc. 1984 May;59(5):343-6. doi: 10.1016/s0025-6196(12)61431-1.

Abstract

Asymptomatic pulmonary infiltrates and eosinophilia developed in a patient with chronic ulcerative colitis 1 month after therapy with sulfasalazine had been instituted. The abnormalities resolved completely after use of the drug was discontinued. The sulfapyridine component of the sulfasalazine was the likely causative agent because 41 years earlier, the patient had experienced fever, myalgias, and eosinophilia after taking a sulfonamide. Ten previous cases of sulfasalazine pulmonary toxicity, including one fatality, have been reported.

摘要

一名患有慢性溃疡性结肠炎的患者在开始使用柳氮磺胺吡啶治疗1个月后出现无症状性肺部浸润和嗜酸性粒细胞增多。停用该药物后，这些异常情况完全消失。柳氮磺胺吡啶中的磺胺吡啶成分可能是致病因素，因为41年前该患者在服用磺胺类药物后曾出现发热、肌痛和嗜酸性粒细胞增多。此前已报告过10例柳氮磺胺吡啶引起的肺部毒性病例，其中包括1例死亡病例。