Panayiotou B N
Barnet General Hospital, England.
Aust N Z J Med. 1991 Jun;21(3):348-9. doi: 10.1111/j.1445-5994.1991.tb04705.x.
A case of blood eosinophilia with pulmonary infiltrates associated with sulphasalazine therapy in a patient with ulcerative colitis is described. These manifestations resolved when sulphasalazine was ceased and recurred with rechallenge. The failure of recurrence after treatment with mesalazine (5-aminosalicyclic acid in a sustained release preparation) suggests that sulphapyridine is the component responsible for this reaction.
本文描述了一例溃疡性结肠炎患者在使用柳氮磺胺吡啶治疗时出现血液嗜酸性粒细胞增多伴肺部浸润的病例。停用柳氮磺胺吡啶后这些表现消失，再次使用时又复发。用美沙拉嗪（缓释制剂中的5-氨基水杨酸）治疗后未再复发，提示磺胺吡啶是引起该反应的成分。
