艾滋病——一种自身免疫模型。

AIDS--an autoimmune model.

作者信息

Kennedy J R

出版信息

Med Hypotheses. 1992 Jan;37(1):16-9. doi: 10.1016/0306-9877(92)90005-w.

Abstract

In AIDS a complementary interface between the HIV virus and the CD4 molecule of the T4 lymphocyte suggest a possible cause of immune self-recognition. Because of this complementarity, an anti-idiotypic immune response to the CD4 attachment area of HIV should result in an autoimmune reaction to CD4 positive lymphocytes. Experimental demonstration of such an immune recognition model by autoreactive lymphocytes is presented and a hypothetical immune response unit is suggested.

摘要

在艾滋病中，人类免疫缺陷病毒（HIV）与T4淋巴细胞的CD4分子之间的互补界面提示了免疫自我识别的一种可能原因。由于这种互补性，针对HIV的CD4附着区域的抗独特型免疫反应应会导致对CD4阳性淋巴细胞的自身免疫反应。本文展示了自身反应性淋巴细胞对这种免疫识别模型的实验证明，并提出了一种假设的免疫反应单位。