MacDonald P C, Edman C D, Kerber I J, Siiteri P K
Gynecol Invest. 1976;7(3):165-75.
The utilization of plasma dehydroisoandrosterone for estrogen production was studied in 4 normal young nonpregnant women and in one young surgical castrate woman. The mean transfer constant for total conversion to estrogen, [sigma] DE-BU' was 0.0016 of which about one third (0.0005) could be accounted for by conversion of dehydroisoandrosterone first to plasma androstenedione which in turn was converted to estrone. The remaining fractional conversion appeared to result principally in estradiol formation via a pathway probably not involving plasma androstenedione. The conversion of plasma dehydroisoandrosterone to estrogen was similar in the surgical castrate to that observed in the ovulating women. It is concluded that plasma dehydroisoandrosterone is converted to estrogen at extraglandular site(s) but this contribution represents only a minor fraction of total estrogen production in normal young women.
在4名正常、年轻、未怀孕的女性以及1名年轻的手术去势女性中，研究了利用血浆脱氢表雄酮生成雌激素的情况。向雌激素完全转化的平均转移常数[σ]DE-BU'为0.0016，其中约三分之一（0.0005）可归因于脱氢表雄酮先转化为血浆雄烯二酮，而后者又转化为雌酮。其余部分的转化似乎主要通过可能不涉及血浆雄烯二酮的途径生成雌二醇。手术去势女性中血浆脱氢表雄酮向雌激素的转化与排卵女性中观察到的情况相似。结论是，血浆脱氢表雄酮在腺外部位转化为雌激素，但这种贡献仅占正常年轻女性雌激素总生成量的一小部分。
