Dumic M, Tajic M, Mardesic D, Kalafatic Z
Arch Dis Child. 1982 Mar;57(3):200-3. doi: 10.1136/adc.57.3.200.
Endocrine studies in girls with precocious thelarche were compared with those of normal girls of similar ages. Girls with precocious thelarche showed breast development and oestrogenised vaginal smears as the only signs of precocious sexual development. A few of the girls were tall and some had advanced bone ages but these two findings were not consistently present in the same patient. Hormones--such as serum oestradiol, oestrone, delta 4-androstenedione, progesterone, dehydroepiandrosterone (DHEA), follicle-stimulating hormone, luteinising hormone, and prolactin, and urinary 17-ketosteroids--were measured. Only DHEA was different, being higher in girls with precocious thelarche. It is suggested that the high DHEA level may serve as a precursor for conversion to oestrogens in target tissues, breast, and vagina. This mechanism for oestrogenisation had been reported in other patients.
对患有性早熟乳房过早发育的女孩进行了内分泌研究，并与年龄相仿的正常女孩进行了比较。患有性早熟乳房过早发育的女孩表现出乳房发育和雌激素化的阴道涂片，这是性早熟的唯一迹象。少数女孩身材高大，一些女孩骨龄提前，但这两个发现并非在同一患者中始终出现。检测了血清雌二醇、雌酮、δ4-雄烯二酮、孕酮、脱氢表雄酮（DHEA）、促卵泡激素、促黄体生成素、催乳素等激素以及尿17-酮类固醇。只有脱氢表雄酮有所不同，在患有性早熟乳房过早发育的女孩中较高。有人认为，高脱氢表雄酮水平可能是靶组织（乳房和阴道）中转化为雌激素的前体。这种雌激素化机制在其他患者中已有报道。
