Jurczok F
Fortschr Med. 1976 Mar 18;94(9):524-7.
A total of 387 women with severe climacteric complaints were treated for a period of 4 years with a new combined hormone preparation containing 200 mg DHEAO (dehydroepiandrosterone oenanthate) and 4 mg oestradiol valerate in 1 ml oily solution. As a depot preparation it has a duration of action of about 6 weeks when administered parenterally. The therapeutic effect is as good as that of the known androgen-oestrogen combinations. There were no observations of voice changes or hirsutism as signs of virilisation. Hormone-cytological studies in all cases showed that proliferation of the endometrium in the sense of hyperplasia cannot be induced by the administered hormones. Cytologically, there is no evidence at all for an androgenic effect. With the exception of transient mastodynia, no mammary changes were observed. Curettage must be performed in existing or suddenly occurring bleeding disturbances, and continuous cytological and hormone-cytological studies are advisable.
共有387名有严重更年期症状的女性接受了一种新的复合激素制剂治疗，为期4年。该制剂为1毫升油溶液，含200毫克DHEAO（庚酸脱氢表雄酮）和4毫克戊酸雌二醇。作为一种长效制剂，经肠胃外给药时作用持续时间约为6周。其治疗效果与已知的雄激素 - 雌激素组合相当。未观察到声音变化或多毛症等男性化迹象。所有病例的激素细胞学研究表明，所给予的激素不会诱发子宫内膜增生意义上的增殖。从细胞学角度看，完全没有雄激素作用的证据。除了短暂的乳房疼痛外，未观察到乳腺变化。对于现有的或突然出现的出血紊乱情况必须进行刮宫，持续的细胞学和激素细胞学研究是可取的。
