人类免疫缺陷病毒阳性患者中鸟分枝杆菌-胞内分枝杆菌复合体菌血症的发病率

Incidence of Mycobacterium avium-intracellulare complex bacteremia in human immunodeficiency virus-positive patients.

作者信息

Nightingale S D, Byrd L T, Southern P M, Jockusch J D, Cal S X, Wynne B A

机构信息

University of Texas Southwestern Medical School, Dallas.

出版信息

J Infect Dis. 1992 Jun;165(6):1082-5. doi: 10.1093/infdis/165.6.1082.

DOI:10.1093/infdis/165.6.1082

PMID:1349906

Abstract

The product-limit incidence of Mycobacterium avium-intracellulare complex (MAC) bacteremia in 1006 human immunodeficiency virus (HIV)-positive patients followed at one institution over a 3-year period from the day of AIDS diagnosis with monthly lysis-centrifugation blood cultures was 21% +/- 2% SE at 1 year and 43% +/- 3% at 2 years. The product-limit incidence of MAC bacteremia at 1 year after the patients' first CD4 cell count was related to both the CD4 cell count and to whether they had an AIDS diagnosis (both P less than .0001) but not to age, sex, or race. This incidence was 39% +/- 6% for CD4 cell counts of less than 10/mm3, 30% +/- 5% for 10-19/mm3, 20% +/- 4% for 20-39/mm3, 15% +/- 4% for 40-59/mm3, 8% +/- 3% for 60-99/mm3, and 3% +/- 1% for 100-199/mm3. MAC may eventually infect most if not all HIV-positive patients who do not die from another HIV-related event.

摘要

在一家机构对1006例人类免疫缺陷病毒（HIV）阳性患者进行为期3年的随访，自艾滋病诊断之日起每月进行裂解离心血液培养，鸟分枝杆菌-胞内分枝杆菌复合体（MAC）菌血症的乘积限发病率在1年时为21%±2%（标准误），2年时为43%±3%。患者首次CD4细胞计数后1年时MAC菌血症的乘积限发病率与CD4细胞计数以及是否诊断为艾滋病均相关（P均小于0.0001），但与年龄、性别或种族无关。CD4细胞计数低于10/mm³时，该发病率为39%±6%；10 - 19/mm³时为30%±5%；20 - 39/mm³时为20%±4%；40 - 59/mm³时为15%±4%；60 - 99/mm³时为8%±3%；100 - 199/mm³时为3%±1%。MAC最终可能会感染大多数（如果不是全部）未死于其他HIV相关事件的HIV阳性患者。