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新诊断的HIV/AIDS患者中，播散性分枝杆菌感染继发免疫重建炎症综合征与噬血细胞性淋巴组织细胞增生症的重叠综合征

Overlap Syndrome of Immune Reconstitution Inflammatory Syndrome Secondary to Disseminated Mycobacterial Infection and Hemophagocytic Lymphohistiocytosis in a Patient With Newly Diagnosed HIV/AIDS.

作者信息

Patel Nishant, Chastain Cody

机构信息

Infectious Diseases, Vanderbilt University Medical Center, Nashville, USA.

出版信息

Cureus. 2024 Feb 1;16(2):e53410. doi: 10.7759/cureus.53410. eCollection 2024 Feb.

DOI:10.7759/cureus.53410
PMID:38435199
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10908438/
Abstract

Immune reconstitution inflammatory syndrome (IRIS) following initiation of antiretroviral therapy (ART) has variable incidence but is not uncommon and has the potential to cause long-term consequences and fatal outcomes in patients with HIV. Hemophagocytic lymphohistiocytosis (HLH) is a separate syndrome of excess immune activation, but may coexist with IRIS and necessitate a unique treatment approach. In this report, the case of a patient with newly diagnosed HIV/AIDS who was found to have both mycobacterial IRIS and HLH is presented.

摘要

抗逆转录病毒疗法（ART）启动后发生的免疫重建炎症综合征（IRIS）发病率不一，但并不罕见，有可能给HIV患者带来长期后果和致命结局。噬血细胞性淋巴组织细胞增生症（HLH）是一种免疫激活过度的独立综合征，但可能与IRIS并存，需要采取独特的治疗方法。在本报告中，介绍了一名新诊断为HIV/AIDS的患者，该患者同时患有分枝杆菌性IRIS和HLH。

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本文引用的文献

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Severe Mycobacterial Immune Reconstitution Inflammatory Syndrome (IRIS) in Advanced Human Immunodeficiency Virus (HIV) Has Features of Hemophagocytic Lymphohistiocytosis and Requires Prolonged Immune Suppression.严重分枝杆菌免疫重建炎症综合征（IRIS）在晚期人类免疫缺陷病毒（HIV）中具有噬血细胞性淋巴组织细胞增生症的特征，需要长期免疫抑制治疗。
Clin Infect Dis. 2023 Feb 8;76(3):e561-e570. doi: 10.1093/cid/ciac717.
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Incidence of AIDS-Defining Opportunistic Infections in a Multicohort Analysis of HIV-infected Persons in the United States and Canada, 2000-2010.2000 - 2010年美国和加拿大HIV感染者多队列分析中艾滋病界定机会性感染的发病率
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Determination of an appropriate cut-off value for ferritin in the diagnosis of hemophagocytic lymphohistiocytosis.确定铁蛋白在噬血细胞性淋巴组织细胞增生症诊断中的合适临界值。
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An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases.美国胸科学会/美国感染病学会官方声明：非结核分枝杆菌病的诊断、治疗与预防
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Pediatr Blood Cancer. 2007 Feb;48(2):124-31. doi: 10.1002/pbc.21039.
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