Tokarevich N K, Freidlin I S, Kuzina V A, Dimitrieva G M, Kaftyreva L A, Artyomenko N K
Leningrad Pasteur Institute of Epidemiology and Microbiology, Sankt Peterburg, U.S.S.R.
Acta Virol. 1992 Jan;36(1):25-31.
It was found that primary immunization with Coxiella burnetii antigen increased mouse resistance to Salmonella typhimurium infection as evidenced by acceleration of bacterial elimination from the peritoneal cavity and a decrease in lethality of experimental animals. The existence of two rises of bactericidal activity of mouse peritoneal cells was ascertained: the "early" on days 1 and 2, and the "late" on day 14 after C. burnetii administration. The first rise was accompanied by some increase in the number of peritoneal cells as well as by some change of their qualitative representation. The second increase of antibacterial activity was detected during the pronounced cellular and humoral immune responses to C. burnetii.
结果发现，用伯氏考克斯氏体抗原进行初次免疫可增强小鼠对鼠伤寒沙门氏菌感染的抵抗力，这可通过细菌从腹腔中清除加速以及实验动物致死率降低得到证明。确定了小鼠腹腔细胞杀菌活性出现两次升高：在给予伯氏考克斯氏体后的第1天和第2天出现“早期”升高，在第14天出现“晚期”升高。第一次升高伴随着腹腔细胞数量的一些增加以及其定性组成的一些变化。第二次抗菌活性增加是在对伯氏考克斯氏体产生明显的细胞和体液免疫反应期间检测到的。
