Tokarevich N K, Daiter A B, Polotsky Y E, Lukácová M, Kazár J, Kartseva N A, Kuzina V A, Efremov V E, Belov A G
Pasteur Institute of Epidemiology and Microbiology, St. Peterburg, Russia.
Acta Virol. 1993 Feb;37(1):29-40.
Biological properties of antigens of whole cells of C. burnetii in phase I (WCI), their residue (CMR) and extract (CME) obtained by extraction of C. burnetti with chloroform/methanol mixture were subjected to a comparative study. It was shown that CME is able to react specifically with sera containing antibodies against WCI. The inoculation of animals with CME, but not with WCI and CMR does not cause changes of humoral and cell immunity to Coxiella and does not strengthen nonspecific antibacterial activity, but it can stimulate the formation of antibodies. Morphological changes of internal organs of mice were most expressed after the CMR inoculation and were practically absent after the CME inoculation.
对第一阶段伯纳特立克次体全细胞抗原（WCI）、其残渣（CMR）以及用氯仿/甲醇混合物提取伯纳特立克次体得到的提取物（CME）的生物学特性进行了比较研究。结果表明，CME能够与含有抗WCI抗体的血清发生特异性反应。用CME接种动物，但不用WCI和CMR接种，不会引起对柯克斯体的体液免疫和细胞免疫变化，也不会增强非特异性抗菌活性，但它可以刺激抗体的形成。小鼠内脏的形态学变化在接种CMR后最为明显，而在接种CME后几乎没有。
