Polotskiĭ Iu E, Daĭter A B, Efremov V E, Kuzina V A, Belov A G, Tokarevich N K, Kartseva N A, Koroleva T V
Zh Mikrobiol Epidemiol Immunobiol. 1991 Sep(9):70-5.
After the intraperitoneal injection of corpuscles of C. burnetii antigen (Ag), phospholipid (PL), and sediment obtained after the extraction of PL from Ag with chloroform-methanol (CM) slight leukocytic reaction developed in the peritoneum on day 1, and on day 2 it could be observed in the liver and in the spleen. Ag induced the most pronounced morphological changes. In the spleen they were manifested by the activation of T- and B-dependent zones of white pulp from day 2 and by the pronounced hyperplasia of reticular cells and macrophages, leading to splenomegaly, by days 7-14. Simultaneously lymphoid-macrophagal granulomas and hepatomegaly developed in the liver. By days 7-14 the foci of necrosis in the liver were caused by the thrombosis of portal veins and were not registered after the injection of PL and CM (and earlier also in experiments with Ag in doses of 0.1-0.3 mg).
腹腔注射伯纳特立克次体抗原（Ag）、磷脂（PL）以及用氯仿 - 甲醇（CM）从Ag中提取PL后得到的沉淀物后，第1天腹膜出现轻微白细胞反应，第2天在肝脏和脾脏中可观察到。Ag诱导的形态学变化最为明显。在脾脏中，从第2天起白髓的T细胞依赖区和B细胞依赖区被激活，到第7 - 14天，网状细胞和巨噬细胞明显增生，导致脾肿大。同时，肝脏出现淋巴 - 巨噬细胞肉芽肿和肝肿大。到第7 - 14天，肝脏的坏死灶是由门静脉血栓形成引起的，注射PL和CM后未出现这种情况（在早期用0.1 - 0.3毫克剂量的Ag进行的实验中也未出现）。
