Ching C B, Lim B G, Lee E J, Ng S C
Department of Chemical Engineering, National University of Singapore.
Chirality. 1992;4(3):174-7. doi: 10.1002/chir.530040308.
The optical resolution of seven beta-blockers which have in common the N-isopropyl-3-aryloxy-2-hydroxypropylamine moiety was carried out by HPLC using the cellulose tris(3,5-dimethylphenylcarbamate) chiral stationary phase to quantitatively characterize the enantioselectivity of these compounds. The capacity factors and separation factors at different column temperature were determined with some qualitative trends derived. A compensation effect was observed for these compounds where there exists an approximately linear relationship between the enantiomeric differences in enthalpic and entropic energies.
使用纤维素三（3,5-二甲基苯基氨基甲酸酯）手性固定相通过高效液相色谱法对七种具有共同的N-异丙基-3-芳氧基-2-羟基丙胺部分的β-受体阻滞剂进行光学拆分，以定量表征这些化合物的对映选择性。测定了不同柱温下的容量因子和分离因子，并得出了一些定性趋势。观察到这些化合物存在补偿效应，其中焓能和熵能的对映体差异之间存在近似线性关系。
