Vorstrup S, Zbornikova V, Sjöholm H, Skoglund L, Ryding E
Department of Neurology, Rigshospitalet, Copenhagen, Denmark.
Neurol Res. 1992 Mar;14(1):31-8. doi: 10.1080/01616412.1992.11740007.
Cerebral blood flow (CBF) and the cerebral vasoreactivity was measured in patients with cerebrovascular disease and longstanding occlusion of the common carotid artery (CCA). In addition, regional CBF was correlated with transcranial doppler (TCD) measurements at baseline and during 6% CO2 inhalation and after intravenous administration of 1 g of acetazolamide. Twelve patients with a mean age of 62 years (range 45 to 71 years) were included, and the data compared to age-matched healthy controls. CBF was measured by intravenous injection of xenon-133 and SPECT (Tomomatic 564). TCD of the middle cerebral artery (MCA) was done by EME TC-64B. A very low global CBF value of 28 +/- 5 (SD) ml 100 g-1 min-1 was found at baseline as compared to 55 +/- 5 ml 100 g-1 min-1 in the normal controls. During 6% CO2-inhalation and after acetazolamide administration, CBF increased by 58 +/- 24% and 51 +/- 21%, respectively, indicating substantial collateral supply. Correlative analysis of CBF in the MCA territory and TCD in the MCA showed statistical significance only for the pooled data, i.e. compiling the data obtained during baseline and the two vasodilatory tests, and then only for the mean and peak TCD velocity (e.g. r = 0.59, p less than 0.002, n = 35, mean velocity, right side). We conclude that TCD measurements do not predict regional CBF in patients with CCA occlusion. The study emphasizes that these two methods yield supplementary information, with TCD measurements providing information of the circle of Willis and CBF studies of the flow distribution.
对患有脑血管疾病且颈总动脉（CCA）长期闭塞的患者进行了脑血流量（CBF）和脑血管反应性测量。此外，还将局部CBF与基线时、吸入6%二氧化碳期间以及静脉注射1克乙酰唑胺后的经颅多普勒（TCD）测量结果进行了相关性分析。纳入了12名平均年龄为62岁（范围45至71岁）的患者，并将数据与年龄匹配的健康对照进行比较。通过静脉注射氙-133和单光子发射计算机断层扫描（Tomomatic 564）测量CBF。通过EME TC-64B对大脑中动脉（MCA）进行TCD检查。与正常对照组的55±5 ml 100 g-1 min-1相比，基线时发现极低的全脑CBF值为28±5（标准差）ml 100 g-1 min-1。在吸入6%二氧化碳期间和给予乙酰唑胺后，CBF分别增加了58±24%和51±21%，表明存在大量侧支供血。对MCA区域的CBF和MCA的TCD进行相关性分析，仅对汇总数据具有统计学意义，即汇总基线时和两次血管舒张试验期间获得的数据，然后仅对平均和峰值TCD速度具有统计学意义（例如，r = 0.59，p < 0.（此处原文有误，推测应为p < 0.002），n = 35，平均速度，右侧）。我们得出结论：TCD测量不能预测CCA闭塞患者的局部CBF。该研究强调这两种方法可提供补充信息，TCD测量提供 Willis 环的信息，而CBF研究提供血流分布的信息。
