脑血流和速度：磁共振成像与经颅多普勒超声的相关性。
Brain blood flow and velocity: correlations between magnetic resonance imaging and transcranial Doppler sonography.
机构信息
Department of Neurology, Stroke Division, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02117, USA.
出版信息
J Ultrasound Med. 2010 Jul;29(7):1017-22. doi: 10.7863/jum.2010.29.7.1017.
OBJECTIVE
Because transcranial Doppler sonography (TCD) is unable to measure arterial diameter, it remains unproven whether the changes in cerebral blood velocity it measures are representative of changes in cerebral blood flow (CBF). Our study was designed to compare velocity changes with flow changes measured by two magnetic resonance imaging (MRI) techniques, perfusion MRI and arterial spin labeling (ASL), using flavanol-rich cocoa to induce CBF changes in healthy volunteers.
METHODS
We enrolled 20 healthy volunteers aged 62 to 80 years (mean, 73 years). Each was studied at baseline and after drinking standardized servings of cocoa for 7 to 14 days.
RESULTS
Changes in middle cerebral artery (MCA) flow by TCD were significantly correlated with changes in perfusion assessed by gadolinium-enhanced MRI (r = 0.63; P < .03). Measurements with ASL showed a stronger correlation with borderline significance.
CONCLUSIONS
Changes in flow velocity in the MCA associated with drinking cocoa were highly correlated with changes in CBF measured by the two MRI techniques using the tracer gadolinium and ASL. These results validate Doppler measurements of CBF velocity as representative assessments of CBF.
目的
由于经颅多普勒超声（TCD）无法测量动脉直径，因此它所测量的血流速度变化是否代表脑血流（CBF）变化仍未得到证实。我们的研究旨在比较两种磁共振成像（MRI）技术——灌注 MRI 和动脉自旋标记（ASL）测量的流速变化与流量变化，使用富含黄烷醇的可可诱导健康志愿者的 CBF 变化。
方法
我们招募了 20 名年龄在 62 岁至 80 岁（平均 73 岁）的健康志愿者。每位志愿者在基线时和饮用可可标准化剂量 7 至 14 天后进行研究。
结果
TCD 测量的大脑中动脉（MCA）流量变化与钆增强 MRI 评估的灌注变化显著相关（r = 0.63；P <.03）。ASL 的测量结果与边缘显著相关。
结论
饮用可可后 MCA 血流速度的变化与使用示踪剂钆和 ASL 的两种 MRI 技术测量的 CBF 变化高度相关。这些结果验证了 TCD 对 CBF 速度的测量可作为 CBF 的代表性评估。
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