Diezel W, Gruner S, Anhalt G J
Dermatologische Klinik und Poliklinik, Universität zu Rostock.
Hautarzt. 1992 Jan;43(1):22-4.
Both, ammonium bituminosulfonate (Ichthyol) and Pix lithanthracis reduce the number of ATPase-positive epidermal Langerhans cells (ELC) in the epidermis of BALB/c mice: vaselinum flavum alone vs vaselinum flavum +5% Ichthyol: P less than 0.01; vaselinum flavum vs vaselinum flavum +5% Pix lithanthracis: P less than 0.001. In contrast to this, the number of Ia-positive cells was not changed under identical conditions. These results allow the conclusion that Ichthyol and Pix lianthracis are able to inhibit the enzyme ATPase on the surface of ELC. We infer that inhibition of ELC ATPase may be important in the regulation of ELC function (inhibition of cutaneous contact hypersensitivity).
磺酸铵沥青（鱼石脂）和煤焦油均能减少BALB/c小鼠表皮中ATP酶阳性的表皮朗格汉斯细胞（ELC）数量：单独使用凡士林与凡士林+5%鱼石脂相比：P<0.01；凡士林与凡士林+5%煤焦油相比：P<0.001。与此相反，在相同条件下，Ia阳性细胞的数量没有变化。这些结果表明，鱼石脂和煤焦油能够抑制ELC表面的ATP酶。我们推测，抑制ELC的ATP酶可能在ELC功能调节（抑制皮肤接触性超敏反应）中起重要作用。
