Diezel W, Schewe T, Rohde E, Rosenbach T, Czarnetzki B M
Dermatologische Klinik und Poliklinik Universität Rostock.
Hautarzt. 1992 Dec;43(12):772-4.
Ammonium bituminosulphonate (Ichthyol) inhibits 5-lipoxygenase activity in human polymorphonuclear neutrophils. The inhibition is dose-dependent and occurs at non-cytotoxic concentrations of the drug. This results in a decreased release of Leukotriene B4 from polymorphonuclear neutrophils. Furthermore, when applied to the ear skin of AB/Bln mice pretreated with croton oil, Ichthyol reduces the inflammatory reaction.
鱼石脂（磺酸铵沥青）可抑制人多形核中性粒细胞中的5-脂氧合酶活性。这种抑制作用呈剂量依赖性，且在该药物的非细胞毒性浓度下即可发生。这导致多形核中性粒细胞中白三烯B4的释放减少。此外，将鱼石脂应用于预先用巴豆油处理过的AB/Bln小鼠耳部皮肤时，可减轻炎症反应。
