WEIGLE W O
J Exp Med. 1958 May 1;107(5):653-63. doi: 10.1084/jem.107.5.653.
The immune elimination of soluble BSA, following an intravenous injection, is accompanied by the appearance of circulating antigen-antibody complexes. The pattern of the appearance of circulating antigen-antibody complexes and the immune elimination of antigen probably depends on the amount of antigen injected, the rate of antibody synthesis, and perhaps, the quality of antibody produced. There is no relationship between the I* antigen-antibody complexes detected during the immune response in rabbits by ammonium sulfate precipitation and the material precipitated from immune sera as a result of treatment with alkali. Alkali-precipitable material present in the serum of rabbits at a time when I* antigen is also present contain at most only traces of the antigen.
静脉注射后，可溶性牛血清白蛋白的免疫清除伴随着循环抗原 - 抗体复合物的出现。循环抗原 - 抗体复合物的出现模式以及抗原的免疫清除可能取决于注射的抗原量、抗体合成速率，或许还取决于产生的抗体质量。通过硫酸铵沉淀在兔免疫反应期间检测到的I抗原 - 抗体复合物与用碱处理免疫血清后沉淀的物质之间没有关系。在I抗原也存在时，兔血清中存在的碱可沉淀物质最多仅含有痕量抗原。
