Chiu H, Shum P, Lau J, Lam L, Lee S
Department of Psychiatry, Chinese University of Hong Kong.
Am J Psychiatry. 1992 Aug;149(8):1081-5. doi: 10.1176/ajp.149.8.1081.
Only scanty information on the prevalence of tardive dyskinesia in Chinese patients has been available. This study was undertaken to examine the prevalence of tardive dyskinesia, tardive dystonia, and respiratory dyskinesia in Chinese psychiatric patients in Hong Kong.
All inpatients of a mental hospital in Hong Kong, except those in the admission and children's wards, were surveyed with the Abnormal Involuntary Movement Scale, and standard research criteria were used to establish the diagnosis of tardive dyskinesia. In addition, patients were screened for tardive dystonia, according to published criteria, and for respiratory dyskinesia by physical examination and laboratory tests.
Among the 917 patients surveyed, the prevalence rates were 9.3% for tardive dyskinesia, 0.4% for tardive dystonia, and 1.2% for respiratory dyskinesia. With multivariate analysis, greater age and a lower current dose of antipsychotic, but not the presence of mood disorder, were factors found to be significantly associated with tardive dyskinesia.
The prevalence rates were much lower than those found in Western studies. This may indicate that there is an ethnic difference in the prevalence of these conditions. Prospective cross-cultural studies are necessary to explore this possibility.
关于中国患者迟发性运动障碍患病率的信息一直很少。本研究旨在调查香港中国精神科患者中迟发性运动障碍、迟发性肌张力障碍和呼吸运动障碍的患病率。
对香港一家精神病院的所有住院患者进行调查，入院病房和儿童病房的患者除外，使用异常不自主运动量表进行评估，并采用标准研究标准诊断迟发性运动障碍。此外，根据已发表的标准对患者进行迟发性肌张力障碍筛查，并通过体格检查和实验室检查对呼吸运动障碍进行筛查。
在917名接受调查的患者中，迟发性运动障碍的患病率为9.3%，迟发性肌张力障碍为0.4%，呼吸运动障碍为1.2%。多因素分析显示，年龄较大和当前抗精神病药物剂量较低与迟发性运动障碍显著相关，但心境障碍的存在与之无关。
这些患病率远低于西方研究中的患病率。这可能表明这些疾病的患病率存在种族差异。有必要进行前瞻性跨文化研究来探讨这种可能性。
