Pamer E G, Wang C R, Flaherty L, Lindahl K F, Bevan M J
Howard Hughes Medical Institute, Department of Immunology, Seattle, Washington.
Cell. 1992 Jul 24;70(2):215-23. doi: 10.1016/0092-8674(92)90097-v.
We report evidence that a major histocompatibility complex-encoded nonclassic class I molecule presents a foreign peptide to cytotoxic T lymphocytes (CTL) during an infection. Mice immunized with virulent Listeria monocytogenes generate CD8+ CTL with alpha beta receptors specific for a bacterial peptide presented by a conserved class I molecule encoded in the M region of the major histocompatibility complex. The Listeria peptide is digested by carboxypeptidase Y but resists aminopeptidase M, and only peptides with N-formyl methionine competitively block its presentation to CTL. Transfection with the H-2M3d gene enables a negative (H-2w17) cell line to present the bacterial peptide. One function, therefore, of H-2M3 is to present bacterial peptides to CTL during infection.
我们报告了一项证据，表明一种主要组织相容性复合体编码的非经典I类分子在感染期间将一种外来肽呈递给细胞毒性T淋巴细胞（CTL）。用强毒单核细胞增生李斯特菌免疫的小鼠产生了具有αβ受体的CD8 + CTL，这些受体对主要组织相容性复合体M区域编码的保守I类分子呈递的一种细菌肽具有特异性。李斯特菌肽可被羧肽酶Y消化，但对氨肽酶M具有抗性，只有带有N - 甲酰甲硫氨酸的肽才能竞争性地阻断其向CTL的呈递。用H - 2M3d基因转染可使一个阴性（H - 2w17）细胞系呈递这种细菌肽。因此，H - 2M3的一个功能是在感染期间将细菌肽呈递给CTL。
