Qiu Zhijuan, Khairallah Camille, Sheridan Brian S
Department of Molecular Genetics & Microbiology, Center for Infectious Diseases, Stony Brook University, Stony Brook, NY 11790, USA.
Pathogens. 2018 Jun 16;7(2):55. doi: 10.3390/pathogens7020055.
() infection induces robust CD8 T cell responses, which play a critical role in resolving during primary infection and provide protective immunity to re-infections. Comprehensive studies have been conducted to delineate the CD8 T cell response after infection. In this review, the generation of the CD8 T cell response to infection will be discussed. The role of dendritic cell subsets in acquiring and presenting antigens to CD8 T cells and the events that occur during T cell priming and activation will be addressed. CD8 T cell expansion, differentiation and contraction as well as the signals that regulate these processes during infection will be explored. Finally, the formation of memory CD8 T cell subsets in the circulation and in the intestine will be analyzed. Recently, the study of CD8 T cell responses to infection has begun to shift focus from the intravenous infection model to a natural oral infection model as the humanized mouse and murinized have become readily available. Recent findings in the generation of CD8 T cell responses to oral infection using murinized will be explored throughout the review. Finally, CD8 T cell-mediated protective immunity against infection and the use of as a vaccine vector for cancer immunotherapy will be highlighted. Overall, this review will provide detailed knowledge on the biology of CD8 T cell responses after infection that may shed light on improving rational vaccine design.
（）感染可诱导强烈的CD8 T细胞反应，这在原发性感染期间解决感染过程中起关键作用，并为再次感染提供保护性免疫。已经进行了全面的研究来描绘感染后的CD8 T细胞反应。在这篇综述中，将讨论针对感染的CD8 T细胞反应的产生。将探讨树突状细胞亚群在获取和呈递抗原给CD8 T细胞中的作用以及T细胞启动和激活期间发生的事件。将探索感染期间CD8 T细胞的扩增、分化和收缩以及调节这些过程的信号。最后，将分析循环系统和肠道中记忆CD8 T细胞亚群的形成。最近，随着人源化小鼠和鼠源化的 变得容易获得，对感染的CD8 T细胞反应的研究已开始从静脉感染模型转向天然口服感染模型。在整个综述中，将探讨使用鼠源化 对口服感染产生CD8 T细胞反应的最新发现。最后，将强调CD8 T细胞介导的针对感染的保护性免疫以及作为癌症免疫治疗疫苗载体的用途。总体而言，这篇综述将提供有关感染后CD8 T细胞反应生物学的详细知识，这可能有助于改进合理的疫苗设计。
