• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
In vitro anti-tumor activity of anti-c-erbB-2 x anti-CD3 epsilon bifunctional monoclonal antibody.抗c-erbB-2×抗CD3ε双功能单克隆抗体的体外抗肿瘤活性
Jpn J Cancer Res. 1992 Jun;83(6):563-7. doi: 10.1111/j.1349-7006.1992.tb00126.x.
2
Human c-erbB-2 proto-oncogene product as a target for bispecific-antibody-directed adoptive tumor immunotherapy.人c-erbB-2原癌基因产物作为双特异性抗体导向的过继性肿瘤免疫疗法的靶点。
Int J Cancer. 1992 Mar 12;50(5):800-4. doi: 10.1002/ijc.2910500523.
3
Specific cytolysis of HIV-infected cells by lymphocytes armed with bifunctional antibodies.
Immunol Lett. 1992 Feb 15;31(3):247-52. doi: 10.1016/0165-2478(92)90122-5.
4
Specific targeting of in vitro-activated human antitumour effector cells using anti-CD3 x anti-c-erbB-2 bispecific antibody.使用抗CD3×抗c-erbB-2双特异性抗体对体外激活的人抗肿瘤效应细胞进行特异性靶向。
Immunol Cell Biol. 1993 Apr;71 ( Pt 2):109-15. doi: 10.1038/icb.1993.11.
5
Anti-tumor X anti-lymphocyte heteroconjugates augment colon tumor cell lysis in vitro and prevent tumor growth in vivo.
Dis Colon Rectum. 1991 Feb;34(2):140-7. doi: 10.1007/BF02049988.
6
Increased lysis of patient CD10-positive leukemic cells by T cells coated with anti-CD3 Fab' antibody cross-linked to anti-CD10 Fab' antibody.用与抗CD10 Fab'抗体交联的抗CD3 Fab'抗体包被的T细胞对患者CD10阳性白血病细胞的裂解增加。
Blood. 1991 Mar 1;77(5):1044-9.
7
Bispecific F (ab')2 monomer prepared with anti-CD3 and anti-tumor monoclonal antibodies is most potent in induction of cytolysis of human T cells.用抗CD3和抗肿瘤单克隆抗体制备的双特异性F(ab')2单体在诱导人T细胞细胞溶解方面最有效。
Eur J Immunol. 1989 Aug;19(8):1437-41. doi: 10.1002/eji.1830190814.
8
Induction of cytotoxicity in human T cells coated with anti-glioma x anti-CD3 bispecific antibody against human glioma cells.抗人胶质瘤x抗CD3双特异性抗体包被的人T细胞对人胶质瘤细胞的细胞毒性诱导作用。
J Neurosurg. 1990 Mar;72(3):476-81. doi: 10.3171/jns.1990.72.3.0476.
9
Targeted cellular immunotherapy with bifunctional antibodies.双功能抗体的靶向细胞免疫疗法。
Cancer Cells. 1991 May;3(5):163-72.
10
Anti-CD3 x anti-tumor F(ab')2 bifunctional antibody activates and retargets tumor-infiltrating lymphocytes.抗CD3×抗肿瘤F(ab')2双功能抗体激活并重新靶向肿瘤浸润淋巴细胞。
J Immunol. 1995 Aug 1;155(3):1296-303.

本文引用的文献

1
Distinctive functional characteristics of human "T" lymphocytes defined by E rosetting or a monoclonal anti-T cell antibody.通过E玫瑰花结形成或单克隆抗T细胞抗体所界定的人“T”淋巴细胞的独特功能特性。
Eur J Immunol. 1981 Apr;11(4):329-34. doi: 10.1002/eji.1830110412.
2
Preparation of F(ab')2 fragments from mouse IgG of various subclasses.从各种亚类的小鼠IgG制备F(ab')2片段。
J Immunol Methods. 1983 Jan 28;56(2):235-43. doi: 10.1016/0022-1759(83)90415-5.
3
Hybrid hybridomas and their use in immunohistochemistry.杂交杂交瘤及其在免疫组织化学中的应用。
Nature. 1983;305(5934):537-40. doi: 10.1038/305537a0.
4
Preparation of bispecific antibodies by chemical recombination of monoclonal immunoglobulin G1 fragments.通过单克隆免疫球蛋白G1片段的化学重组制备双特异性抗体。
Science. 1985 Jul 5;229(4708):81-3. doi: 10.1126/science.3925553.
5
Regression of cutaneous metastatic melanoma by intralesional injection with human monoclonal antibody to ganglioside GD2.通过病灶内注射抗神经节苷脂GD2人单克隆抗体使皮肤转移性黑色素瘤消退。
Proc Natl Acad Sci U S A. 1986 Nov;83(22):8694-8. doi: 10.1073/pnas.83.22.8694.
6
Human ovarian carcinoma lysis by cytotoxic T cells targeted by bispecific monoclonal antibodies: analysis of the antibody components.双特异性单克隆抗体靶向的细胞毒性T细胞对人卵巢癌的裂解作用：抗体成分分析
Int J Cancer. 1988 Apr 15;41(4):609-15. doi: 10.1002/ijc.2910410422.
7
Overexpression of the EGF receptor-related proto-oncogene erbB-2 in human mammary tumor cell lines by different molecular mechanisms.表皮生长因子受体相关原癌基因erbB-2在人乳腺肿瘤细胞系中通过不同分子机制实现过表达。
EMBO J. 1987 Mar;6(3):605-10. doi: 10.1002/j.1460-2075.1987.tb04797.x.
8
Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor.人类c-erb-B-2基因编码的蛋白质与表皮生长因子受体的相似性。
Nature. 1986;319(6050):230-4. doi: 10.1038/319230a0.
9
Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells.假定的生长因子受体p185HER2的表达增加会导致NIH 3T3细胞发生转化和肿瘤形成。
Proc Natl Acad Sci U S A. 1987 Oct;84(20):7159-63. doi: 10.1073/pnas.84.20.7159.
10
Effects of CAMPATH-1 antibodies in vivo in patients with lymphoid malignancies: influence of antibody isotype.
Blood. 1989 May 1;73(6):1431-9.

抗c-erbB-2×抗CD3ε双功能单克隆抗体的体外抗肿瘤活性

In vitro anti-tumor activity of anti-c-erbB-2 x anti-CD3 epsilon bifunctional monoclonal antibody.

作者信息

Sugiyama Y, Aihara M, Shibamori M, Deguchi K, Imagawa K, Kikuchi M, Momota H, Azuma T, Okada H, Alper O

机构信息

Viral Diseases Research Division, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.

出版信息

Jpn J Cancer Res. 1992 Jun;83(6):563-7. doi: 10.1111/j.1349-7006.1992.tb00126.x.

DOI:10.1111/j.1349-7006.1992.tb00126.x
PMID:1353752
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5918874/
Abstract

With the aim of developing an effective cancer immunotherapy for common epithelial cancer, a new class of bifunctional antibody (BFA) was developed; one arm of this BFA recognized c-erbB-2 gene product, and the other arm recognized CD3 epsilon, a T-cell specific surface antigen. Application of this BFA with human peripheral blood lymphocytes exhibited specific anti-tumor activity in vitro on a breast tumor cell line, ZR-75-1, which expressed abundant c-erbB-2 gene product on its cell surface. These results indicate that BFA recognizing an oncogene product on cell surface is a potential new agent for cancer immunotherapy.

摘要

为了开发一种针对常见上皮癌的有效癌症免疫疗法，研发了一类新型双功能抗体（BFA）；该BFA的一个臂识别c-erbB-2基因产物，另一个臂识别CD3 ε，一种T细胞特异性表面抗原。将这种BFA与人外周血淋巴细胞一起应用，在体外对乳腺癌细胞系ZR-75-1表现出特异性抗肿瘤活性，该细胞系在其细胞表面表达丰富的c-erbB-2基因产物。这些结果表明，识别细胞表面癌基因产物的BFA是一种潜在的癌症免疫治疗新药物。