假定的生长因子受体p185HER2的表达增加会导致NIH 3T3细胞发生转化和肿瘤形成。
Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells.
作者信息
Hudziak R M, Schlessinger J, Ullrich A
机构信息
Department of Developmental Biology, Genentech, Inc., South San Francisco, CA 94080.
出版信息
Proc Natl Acad Sci U S A. 1987 Oct;84(20):7159-63. doi: 10.1073/pnas.84.20.7159.
The HER2 gene encodes a cell-surface glycoprotein with extensive homology to the epidermal growth factor receptor. Recently it was found to be amplified in about 30% of primary human breast malignancies. In experiments designed to assess the role of the HER2 gene in oncogenesis, we found that overexpression of unaltered HER2 coding sequences in NIH 3T3 cells resulted in cellular transformation and tumorigenesis.
HER2基因编码一种细胞表面糖蛋白，与表皮生长因子受体具有广泛的同源性。最近发现，在大约30%的原发性人类乳腺癌中，该基因会发生扩增。在旨在评估HER2基因在肿瘤发生中作用的实验中，我们发现，在NIH 3T3细胞中未改变的HER2编码序列的过表达会导致细胞转化和肿瘤发生。
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