Makiĭ E A
Fiziol Zh (1978). 1992 May-Jun;38(3):90-5.
Substances modulating calcium permeability of cell membrane (verapamil imidazol, 4-aminopyridine), decreasing motor activity (meprobamate) and blocking adrenoreceptors (clophelin, propranolol, droperidol, aminazine++ have been studied for their action on the monosynaptic discharge of the ventral roots (MD VR) reinforced due to chronic cutting of the spinal cord. It is found that verapamil and meprobamate depress more strongly MD VR of rats with chronic cutting of the spinal cord than of those with the acute one. Imidazol and 4-aminopyridine reinforcing MD VR of rats with acute cutting of the spinal cord have no influence on the analogous index of rats with chronic cutting of the spinal cord. Adrenoblockers do not change the amplitude of MD VR in both groups of the animals.
对细胞膜钙通透性有调节作用的物质（维拉帕米、咪唑、4-氨基吡啶）、降低运动活性的物质（甲丙氨酯）以及阻断肾上腺素能受体的物质（氯苯乙胍、普萘洛尔、氟哌利多、氯丙嗪++），已针对它们对因脊髓慢性横断而增强的腹根单突触放电（MD VR）的作用进行了研究。结果发现，维拉帕米和甲丙氨酯对慢性脊髓横断大鼠的MD VR的抑制作用比对急性脊髓横断大鼠的更强。咪唑和4-氨基吡啶可增强急性脊髓横断大鼠的MD VR，但对慢性脊髓横断大鼠的类似指标没有影响。肾上腺素能阻滞剂在两组动物中均未改变MD VR的幅度。
