[多巴胺对大鼠离体脊髓兴奋性传递的抑制作用]
[Inhibitory action of dopamine on excitatory transmission in the isolated spinal cord of the rat].
作者信息
Oksamitnyĭ V N, Tamarova Z A
出版信息
Neirofiziologiia. 1986;18(5):616-21.
The effect of dopamine on the ventral root potential evoked by single supramaximal dorsal root stimulation was studied in the experiment in the isolated superfused spinal cord of 10-16 days old rats. It was discovered that application of dopamine caused the reversible dose-dependent inhibition of the mono- and polysynaptic ventral root reflex responses. The minimal effective concentration was 1 X 10(-8) mol/l. Dopamine applied in concentrations of 1 X 10(-4) mol/l and 1 X 10(-3) mol/l decreased the amplitude of the monosynaptic ventral root potential by 20% and 87% as against the control, respectively. Under the same conditions the amplitude of the polysynaptic ventral root potential decreased by 18% and 87% as against the control, respectively. The obtained results demonstrate that the dopaminergic brainstem-spinal pathways take part in the control of the transmission in the segmentary reflex arc.
在对10 - 16日龄大鼠的离体灌注脊髓进行的实验中，研究了多巴胺对单次超强背根刺激诱发的腹根电位的影响。发现应用多巴胺会导致单突触和多突触腹根反射反应出现可逆的剂量依赖性抑制。最小有效浓度为1×10（-8）mol/l。以1×10（-4）mol/l和1×10（-3）mol/l浓度应用的多巴胺，与对照组相比，分别使单突触腹根电位的幅度降低了20%和87%。在相同条件下，多突触腹根电位的幅度与对照组相比分别降低了18%和87%。所获得的结果表明，多巴胺能脑干 - 脊髓通路参与节段性反射弧中传导的控制。
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