Serdiuchenko I Ia, Mantulo P M, Karneta I M
Neirofiziologiia. 1986;18(5):702-4.
L5 ventral root reflex discharges evoked by dorsal root stimulation were studied 3-4 weeks after transection of sciatic nerve in rats; only polysynaptic transmission was found on the side of operation. Injection of 4-aminopyridine (500-600 mg/kg, intraperitoneally) resulted in facilitation of reflex discharges on the intact side and in reappearance of intensive monosynaptic component in such discharges on the affected side. It is concluded that 4-aminopyridine recovers monosynaptic transmission between primary afferents and chromatolysed motoneurons because of increased transmitter liberation.
在大鼠坐骨神经横断后3 - 4周，研究了背根刺激诱发的腰5腹根反射放电；在手术侧仅发现多突触传递。腹腔注射4 - 氨基吡啶（500 - 600毫克/千克）导致完整侧反射放电增强，且在患侧此类放电中再次出现强烈的单突触成分。得出的结论是，4 - 氨基吡啶由于递质释放增加，恢复了初级传入神经与经染色质溶解的运动神经元之间的单突触传递。
