Sintenie J B, Tuinebreijer W E, Kreis R W, Breederveld R S
Department of Surgery, Red Cross Hospital, Beverwijk, The Netherlands.
Eur J Surg. 1992 May;158(5):315-6.
A case is described in which inadvertent intra-arterial injection of phenytoin led to digital gangrene, with arteriography showing occlusion of the digital arteries, necessitating amputation of fingers. The high alkalinity of phenytoin is strongly irritant to vessel walls. Intravenous injection of phenytoin should be given only with great care and in emergencies, preferably avoiding the cubital fossa.
本文描述了一例因意外动脉内注射苯妥英钠导致手指坏疽的病例，动脉造影显示指动脉闭塞，不得不进行手指截肢。苯妥英钠的高碱性对血管壁有强烈刺激性。静脉注射苯妥英钠时应格外小心，仅在紧急情况下使用，最好避开肘窝。
