Turner Patricia V, Brabb Thea, Pekow Cynthia, Vasbinder Mary Ann
Department of Pathobiology, University of Guelph, Guelph, Canada.
J Am Assoc Lab Anim Sci. 2011 Sep;50(5):600-13.
Administration of substances to laboratory animals requires careful consideration and planning to optimize delivery of the agent to the animal while minimizing potential adverse experiences from the procedure. For all species, many different routes are available for administration of substances. The research team and IACUC members should be aware of reasons for selecting specific routes and of training and competency necessary for personnel to use these routes effectively. Once a route is selected, issues such as volume of administration, site of delivery, pH of the substance, and other factors must be considered to refine the technique. Inadequate training or inattention to detail during this aspect of a study may result in unintentional adverse effects on experimental animals and confounded results.
给实验动物给药需要仔细考虑和规划，以优化药物输送到动物体内的过程，同时将该操作可能带来的不良影响降至最低。对于所有物种而言，有许多不同的给药途径可供选择。研究团队和机构动物护理与使用委员会（IACUC）成员应了解选择特定给药途径的原因，以及人员有效使用这些途径所需的培训和能力。一旦选定给药途径，就必须考虑诸如给药体积、给药部位、药物pH值等问题以及其他因素，以完善技术。在研究的这一方面，如果培训不足或对细节关注不够，可能会对实验动物造成意外的不良影响，并导致结果混淆。
