尼泊尔HTLV-1感染的血清流行病学研究。

A seroepidemiological study of HTLV-1 infection in Nepal.

作者信息

Ishida T, Takayanagi K, Shotake T, Hirai K, Yuasa I

机构信息

Department of Anthropology, University of Tokyo, Japan.

出版信息

Scand J Infect Dis. 1992;24(3):399-400. doi: 10.3109/00365549209061352.

DOI:10.3109/00365549209061352

PMID:1354887

Abstract

A seroepidemiological survey of antibodies to human T-lymphotropic retrovirus type-1 (HTLV-1) was carried out among 413 residents of Chitwan, Dhapakhel and Katmandu in Nepal. Donor screening was first carried out by the gelatin particle agglutination (PA) tests and positive sera were retested by an improved PA test, indirect immunofluorescence (IF) and Western blotting (WB). Nine sera showed positive reaction in the first PA screening. Among these positive sera, 1 serum was positive in the improved PA test and the IF test but negative in the WB test. This study suggests that the prevalence of HTLV-1 in Nepalese people is negligible.

摘要

在尼泊尔奇特旺、达帕凯尔和加德满都的413名居民中开展了一项针对人类嗜T淋巴细胞病毒1型（HTLV-1）抗体的血清流行病学调查。首先通过明胶颗粒凝集（PA）试验进行供体筛查，对阳性血清采用改良PA试验、间接免疫荧光（IF）和蛋白质印迹法（WB）进行复测。9份血清在首次PA筛查中呈阳性反应。在这些阳性血清中，1份血清在改良PA试验和IF试验中呈阳性，但在WB试验中呈阴性。本研究表明，尼泊尔人群中HTLV-1的流行率可忽略不计。