Vinocur C D, Weintraub W H, Wilensky R J, Coran A G, Dingman R O
Arch Surg. 1976 Oct;111(10):1160-4. doi: 10.1001/archsurg.1976.01360280118019.
A child born without scalp, or dura to cover the brain (aplasia cutis congenita) was successfully treated by a multidiscipline team. A coexisting rupture omphalocele forced a change in treatment from the currently recommended regimen of mandatory early scalp closure. Homograft skin was used to protect the brain during the time the omphalocele was treated and skin flaps were delayed. Fluoroscein dye was utilized to determine flap viability and predicted ischemia until after a third delaying procedure was performed. The successful outcome suggests that the present philosophy of early surgical closure being essential for survival in infants with large cranial defects can be altered and, in fact, permanent full-thickness flaps may be designed, tested for viability, and delayed while homograft skin protects the infant's brain from infection and thrombosis.
一个天生没有头皮或硬脑膜覆盖大脑（先天性皮肤发育不全）的儿童由一个多学科团队成功治愈。同时存在的脐膨出破裂迫使治疗方案从目前推荐的强制性早期头皮闭合方案改变。在治疗脐膨出且延迟皮瓣手术期间，使用同种异体皮肤保护大脑。在进行第三次延迟手术之前，利用荧光素染料确定皮瓣活力并预测缺血情况。成功的结果表明，目前认为早期手术闭合对患有大型颅骨缺损的婴儿生存至关重要的理念可以改变，事实上，可以设计永久性全层皮瓣，测试其活力并延迟手术，同时同种异体皮肤保护婴儿大脑免受感染和血栓形成。
