贝那替嗪：一种新型焦谷氨酰肽酶抑制剂。II. 物理化学性质及结构测定

Benarthin: a new inhibitor of pyroglutamyl peptidase. II. Physico-chemical properties and structure determination.

作者信息

Hatsu M, Naganawa H, Aoyagi T, Takeuchi T

机构信息

Institute of Microbial Chemistry, Tokyo, Japan.

出版信息

J Antibiot (Tokyo). 1992 Jul;45(7):1084-7. doi: 10.7164/antibiotics.45.1084.

DOI:10.7164/antibiotics.45.1084

PMID:1355472

Abstract

Benarthin, a new inhibitor of pyroglutamyl peptidase (PG-peptidase), has been isolated from the culture broth of Streptomyces xanthophaeus MJ244-SF1. The structure of benarthin was determined to be L-(2,3-dihydroxybenzoyl)argininyl-L-threonine by analysis of spectral properties and through chemical studies.

摘要

贝那汀是一种新型焦谷氨酸肽酶（PG - 肽酶）抑制剂，已从黄色链霉菌MJ244 - SF1的培养液中分离出来。通过光谱性质分析和化学研究，确定贝那汀的结构为L -（2,3 - 二羟基苯甲酰基）精氨酰 - L - 苏氨酸。