Stanley J C, Mirakhur R K, Bell P F, Sharpe T D, Clarke R S
Department of Clinical Anaesthesia, Royal Victoria Hospital, Belfast, N. Ireland.
Eur J Anaesthesiol. 1991 Mar;8(2):151-6.
The neuromuscular effects of pipecuronium bromide have been evaluated in 90 adult patients anaesthetized with thiopentone, nitrous oxide in oxygen and intravenous fentanyl with or without halothane. Eighty patients received pipecuronium 45 micrograms kg-1 and the remaining ten 70 micrograms kg-1. A separate group of 10 patients received pancuronium in a dose of 60 micrograms kg-1 (equipotent to pipecuronium 45 micrograms kg-1). Neuromuscular block was measured using a single-twitch or train-of-four mode of stimulation. The time to onset of maximum block with pipecuronium 45 micrograms kg-1 varied between 3.5 and 5.7 min depending on the mode of stimulation and the anaesthetic technique used. The time to 25% recovery of this dose varied between 41 and 54 min. The recovery index (time from 25 to 75% recovery) averaged 29 min. These values were generally similar in the group receiving pancuronium 60 micrograms kg-1. The time to onset of complete block with 70 micrograms kg-1 of pipecuronium averaged 2.5 min and the duration to 25% recovery 95 min. There were no significant changes in heart rate and arterial pressure with the use of pipecuronium. The results show pipecuronium to be a drug resembling pancuronium in its neuromuscular effects when used in equipotent doses.
已在90例成年患者中评估了溴哌库溴铵的神经肌肉效应，这些患者用硫喷妥钠、氧气和笑气以及静脉注射芬太尼麻醉，部分患者加用氟烷。80例患者接受45微克/千克的溴哌库溴铵，其余10例接受70微克/千克。另一组10例患者接受60微克/千克的泮库溴铵（相当于45微克/千克的溴哌库溴铵）。使用单刺激或四个成串刺激模式测量神经肌肉阻滞。45微克/千克溴哌库溴铵达到最大阻滞起效时间根据刺激模式和所用麻醉技术在3.5至5.7分钟之间变化。该剂量恢复至25%的时间在41至54分钟之间。恢复指数（从25%恢复至75%的时间）平均为29分钟。接受60微克/千克泮库溴铵的组中这些值通常相似。70微克/千克溴哌库溴铵达到完全阻滞的起效时间平均为2.5分钟，恢复至25%的持续时间为95分钟。使用溴哌库溴铵时心率和动脉压无显著变化。结果表明，当使用等效剂量时，溴哌库溴铵在神经肌肉效应方面类似于泮库溴铵。
