[硫酸阿托品对豚鼠下丘脑促黄体生成激素释放激素细胞的作用]
[Effects of atropine sulfate on the hypothalamic LH-RH cells of the guinea-pig].
作者信息
Leonardelli J
出版信息
C R Seances Soc Biol Fil. 1976 Oct;170(3):602-5.
PMID:135619
Abstract
A single 30 mg/kg., s.c. injection of atropine sulfate into male guinea pigs produces a storage of LH-RH immunoreactive material in hypothalamic neurons. In diestrus female there is no increase of immunoreactive LH-RH substance in neuron and in eminential terminals; the rate of LH-RH synthesis may be still slight. The LH-RH immunoreactive neuronal increase, in male may be related to an atropine blockade of LH-RH portal cession, perhaps via infundibular dopaminergic neurons.
摘要
给雄性豚鼠皮下注射一次30毫克/千克的硫酸阿托品，会使下丘脑神经元中储存促黄体生成激素释放激素（LH - RH）免疫反应性物质。在动情间期的雌性豚鼠中，神经元和终末中免疫反应性LH - RH物质没有增加；LH - RH的合成速率可能仍然很低。雄性豚鼠中LH - RH免疫反应性神经元的增加可能与阿托品对LH - RH门静脉运输的阻断有关，可能是通过漏斗多巴胺能神经元实现的。
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