Leonardelli J
Ann Endocrinol (Paris). 1977 May-Jun;38(3):235-42.
Ovine prolactine injected at doses of either 31,25 to 500 microgram by lateral intraventricular route in male guinea pigs, affects LH-RH hypothalamic neurons within 2 to 24 hours. After this treatment there is an increase of LH-RH immunoreactive material in eminential terminals and in numerous small granules of hypothalamic neuronal cell bodies. This accumulation of immunoactive LH-RH in pericaryon and in terminals can be interpreted as stimulation of LH-RH synthesis. Preliminary results of radioimmunoassayed plasmatic LH level, 2 h after PRL infusion, are in agreement with this hypothesis. The probability that short feed-back by PRL or PIF secretion would simultaneously be able to check LH-RH secretion is discussed.
通过侧脑室途径向雄性豚鼠注射剂量为31.25至500微克的绵羊催乳素，在2至24小时内会影响下丘脑促性腺激素释放激素（LH-RH）神经元。经过这种处理后，在终末和下丘脑神经元细胞体的许多小颗粒中，LH-RH免疫反应性物质增加。免疫活性LH-RH在细胞核周和终末的这种积累可解释为对LH-RH合成的刺激。催乳素输注2小时后，放射免疫测定血浆LH水平的初步结果与这一假设一致。文中还讨论了催乳素或催乳素抑制因子（PIF）分泌的短反馈同时能够抑制LH-RH分泌的可能性。
