Laegreid L, Conradi N, Hagberg G, Hedner T
Department of Pediatrics II, University of Göteborg, Sweden.
Acta Obstet Gynecol Scand. 1992 Aug;71(6):451-7. doi: 10.3109/00016349209021094.
The psychotropic drug use in mothers to all 73 perinatally dead infants in the city of Gothenburg, Sweden, in 1985-86, was compared to a control group of mothers to 73 surviving infants. Information regarding medication in pregnancy and pre- and perinatal data was collected retrospectively. In addition, serum samples obtained in early pregnancy were screened for benzodiazepines. Eighteen case-mothers used psychotropic drugs during pregnancy compared with 7 control-mothers. The association between psychotropic drug use and perinatal death was significant (p = 0.01). Psychotropic drug use and maternal disorder were closely correlated, but within the case group there were no significant differences between mothers using or not using psychotropic drugs in terms of age, parity or smoking habits. Although the etiology of death could be discussed in the individual infant, we find it noteworthy that the use of psychotropic drugs was so frequent in the mothers of perinatally dead infants.
对1985 - 1986年瑞典哥德堡市73例围产期死亡婴儿的母亲使用精神药物的情况，与73例存活婴儿的母亲组成的对照组进行了比较。关于孕期用药以及产前和围产期数据的信息是通过回顾性收集的。此外，对孕早期采集的血清样本进行了苯二氮䓬类药物筛查。18例病例组母亲在孕期使用了精神药物，而对照组母亲为7例。精神药物使用与围产期死亡之间的关联具有显著性（p = 0.01）。精神药物使用与母亲疾病密切相关，但在病例组中，使用或未使用精神药物的母亲在年龄、产次或吸烟习惯方面没有显著差异。尽管可以针对个别婴儿讨论死亡原因，但我们发现值得注意的是，围产期死亡婴儿的母亲中精神药物的使用如此频繁。
