Whitton P S, Sarna G S, Datla K P, Curzon G
Department of Neurochemistry, Institute of Neurology, London, UK.
Psychopharmacology (Berl). 1991;104(1):81-5. doi: 10.1007/BF02244558.
The novel tricyclic antidepressant drug tianeptine had an antidepressant-like effect on a rat model of depression based on the deficit in open field activity observed on the day after 2 h restraint. Thus, when tianeptine (10 mg/kg IP) was given 2 h after the end of the restraint to either untreated rats or to animals previously given 10 mg/kg of the drug per day for 13 days, then the deficit was opposed. Tianeptine, given acutely but not chronically, moderately enhanced the 5-HT1C receptor-dependent hypolocomotor effect of m-chlorophenylpiperazine (mCPP) but did not alter other 5-HT1 receptor subtype-dependent behaviour. Acute but not chronic tianeptine also decreased 5-HT2 receptor-dependent body shakes induced by 5-hydroxytryptophan. Shakes induced by the 5-HT2 agonist 1-(2,5-dimethoxy-4-iodophenyl)-2 aminopropane (DOI) were unaffected. The results are discussed in relation to the possible mechanism of antidepressant action of tianeptine.
新型三环类抗抑郁药噻奈普汀对基于2小时束缚后次日旷场活动缺陷的大鼠抑郁模型具有抗抑郁样作用。因此，当在束缚结束2小时后给未处理的大鼠或先前连续13天每天给予10mg/kg该药物的动物腹腔注射噻奈普汀（10mg/kg）时，这种缺陷得到了对抗。急性而非慢性给予噻奈普汀适度增强了间氯苯哌嗪（mCPP）的5-HT1C受体依赖性低运动效应，但未改变其他5-HT1受体亚型依赖性行为。急性而非慢性噻奈普汀也减少了5-羟色氨酸诱导的5-HT2受体依赖性身体抖动。5-HT2激动剂1-(2,5-二甲氧基-4-碘苯基)-2-氨基丙烷（DOI）诱导的抖动未受影响。结合噻奈普汀抗抑郁作用的可能机制对结果进行了讨论。
