Jenkins S A, Shields R, Jaser N, Ellenbogen S, Naylor E, Baxter J N
University Department of Surgery, Royal Liverpool University Hospital, UK.
HPB Surg. 1992 Jun;5(4):221-6; discussion 226-7. doi: 10.1155/1992/86987.
Sixteen patients with persistent (n = 11) or recurrent (n = 5) variceal bleeding after injection sclerotherapy and balloon tamponade were treated with an intravenous infusion of somatostatin 250 micrograms/h. Somatostatin infusion successfully controlled the bleeding in 15 of the 16 patients but one rebled after 72 h of treatment. In one patient with poor liver function (Child's C) bleeding was not controlled by somatostatin, further injection sclerotherapy or balloon tamponade of the oesophagus. The results of this study, although uncontrolled and with a small number of patients, suggest that somatostatin is a very effective treatment for the control of post-injection sclerotherapy variceal bleeding.
16例经注射硬化疗法和气囊压迫治疗后仍有持续性（n = 11）或复发性（n = 5）静脉曲张出血的患者，接受了250微克/小时的生长抑素静脉输注治疗。生长抑素输注成功控制了16例患者中15例的出血，但有1例在治疗72小时后再次出血。1例肝功能差（Child's C级）的患者，生长抑素、进一步的注射硬化疗法或食管气囊压迫均未能控制出血。本研究结果虽未设对照且患者数量较少，但提示生长抑素是控制注射硬化疗法后静脉曲张出血的一种非常有效的治疗方法。
