色胺能药物对大鼠电休克格斗行为的影响。

Effect of tryptaminergic drugs on electroshock fighting behaviour in rats.

作者信息

Anand M, Gupta G P, Bhargava K P

出版信息

Eur J Pharmacol. 1976 Oct;39(2):389-91. doi: 10.1016/0014-2999(76)90149-7.

Abstract

The effect of some tryptaminergic drugs on electroshock fighting behaviour in rats was determined. Reserpine and tetrabenazine reduced the fighting responses while 5-hydroxytryptophan increased the fighting responses in normal as well as reserpine-treated animals. p-Chlorophenylalanine, a specific depletor of brain serotonin, also reduced the fighting responses. The results suggest that an increase of brain serotonin may have a facilitatory effect on electroshock fighting behaviour and a decrease of brain serotonin may impair fighting behaviour.

摘要

测定了一些色胺能药物对大鼠电击格斗行为的影响。利血平和丁苯那嗪降低了格斗反应，而5-羟色氨酸在正常动物以及利血平处理的动物中均增加了格斗反应。对氯苯丙氨酸是一种特异性的脑5-羟色胺耗竭剂，它也降低了格斗反应。结果表明，脑5-羟色胺的增加可能对电击格斗行为有促进作用，而脑5-羟色胺的减少可能损害格斗行为。