Weber C J, Hardy M A, Lerner R L, Felig P, Reemtsma K
Diabetes. 1976 Oct;25(10):944-8. doi: 10.2337/diab.25.10.944.
Fasting blood glucose (FBG), serum immunoreactive insulin (IRI), plasma immunoreactive glucagon (IRG), body weight, and caloric intake were measured in long-term islet-isografted rats eight to 10 months following intraperitoneal islet transplantation in in age-matched, sham-operated, concurrently followed normal and diabetic controls. Islet recipients had normal body weights, but they were significantly polyphagic, hyperinsulinemic, and hyperglucagonemic when compared with normals. Fasting blood glucose levels were reduced by 10 per cent. Several factors may be related to the occurrence of these abnormalities in long-term islet-isografted rats, including (1) the mass of islets transplanted, (2) the age of donor tissue, (3) the heterotopic location of islet grafts, and (4) the lack of normal innervation of transplanted islet cells.
在年龄匹配的假手术对照组、同期观察的正常对照组和糖尿病对照组中，对长期胰岛同基因移植大鼠在腹腔内胰岛移植8至10个月后测定空腹血糖（FBG）、血清免疫反应性胰岛素（IRI）、血浆免疫反应性胰高血糖素（IRG）、体重和热量摄入。胰岛移植受体体重正常，但与正常大鼠相比，它们明显多食、高胰岛素血症和高胰高血糖素血症。空腹血糖水平降低了10%。长期胰岛同基因移植大鼠出现这些异常情况可能与几个因素有关，包括（1）移植的胰岛质量，（2）供体组织的年龄，（3）胰岛移植的异位位置，以及（4）移植的胰岛细胞缺乏正常的神经支配。
