ROSENMAN R H, FRIEDMAN M
Calif Med. 1958 Sep;89(3):169-74.
Perhaps because of difficulties inherent in quantitation and evaluation, the possible influence of differences in personality factors and of socio-economic stresses has largely been ignored in epidemiological studies of coronary artery disease. This relationship is explored and it is shown that the major factors contributing to the development of coronary disease, including intimal damage, elevated plasma lipid content, altered hemodynamics and accelerated blood clotting, are each affected by certain types of such stresses. On the basis of the considerable clinical and experimental evidence cited, it is suggested that the increasing occupational stress unique to industrialized society plays a dominant role in the high incidence of clinical coronary heart disease.
或许由于定量和评估存在内在困难，在冠心病的流行病学研究中，人格因素差异和社会经济压力的潜在影响在很大程度上被忽视了。本文探讨了这种关系，并表明导致冠心病发展的主要因素，包括内膜损伤、血浆脂质含量升高、血流动力学改变和血液凝固加速，均受到某些类型此类压力的影响。基于所引用的大量临床和实验证据，有人提出工业化社会特有的日益增加的职业压力在临床冠心病的高发病率中起主导作用。
