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小鼠伏隔核中谷氨酸能和多巴胺能张力之间的相互作用：关于精神运动控制的双重谷氨酸能功能的证据。

Interaction between glutamatergic and dopaminergic tone in the nucleus accumbens of mice: evidence for a dual glutamatergic function with respect to psychomotor control.

作者信息

Svensson A, Carlsson M L, Carlsson A

机构信息

Department of Pharmacology, University of Göteborg, Sweden.

出版信息

J Neural Transm Gen Sect. 1992;88(3):235-40. doi: 10.1007/BF01244735.

DOI:10.1007/BF01244735
PMID:1358121
Abstract

The rotation induced by a unilateral injection of the competitive NMDA receptor antagonist AP-5 was studied in mice with different tone in the central dopaminergic systems. AP-5 induced contralateral rotation in monoamine-depleted mice and in monoamine-depleted mice treated with a dopamine D-1 receptor agonist. In contrast, AP-5 induced predominantly ipsilateral rotation in monoamine-depleted mice treated with a mixed D-1/D-2 or a D-2 selective dopamine agonist and in mice with intact monoaminergic systems.

摘要

在中枢多巴胺能系统具有不同状态的小鼠中，研究了单侧注射竞争性N-甲基-D-天冬氨酸（NMDA）受体拮抗剂AP-5所诱导的旋转。AP-5在单胺耗竭的小鼠以及用多巴胺D-1受体激动剂治疗的单胺耗竭小鼠中诱导对侧旋转。相反，AP-5在用D-1/D-2混合或D-2选择性多巴胺激动剂治疗的单胺耗竭小鼠以及单胺能系统完整的小鼠中主要诱导同侧旋转。

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Presynaptic dopamine-glutamate interactions in the nucleus accumbens regulate sensorimotor gating.伏隔核中的突触前多巴胺-谷氨酸相互作用调节感觉运动门控。
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Interactions between glutamatergic and monoaminergic systems within the basal ganglia--implications for schizophrenia and Parkinson's disease.基底神经节内谷氨酸能系统与单胺能系统之间的相互作用——对精神分裂症和帕金森病的影响。
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Differential locomotor interactions between dopamine D1/D2 receptor agonists and the NMDA antagonist dizocilpine in monoamine-depleted mice.多巴胺 D1/D2 受体激动剂与 N-甲基-D-天冬氨酸（NMDA）拮抗剂地佐环平在单胺耗竭小鼠中的差异性运动相互作用
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Injection of the competitive NMDA receptor antagonist AP-5 into the nucleus accumbens of monoamine-depleted mice induces pronounced locomotor stimulation.向单胺耗竭小鼠的伏隔核注射竞争性N-甲基-D-天冬氨酸（NMDA）受体拮抗剂AP-5会引起明显的运动兴奋。
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