Maslov L N, Lishmanov Iu B
Eksp Klin Farmakol. 1992 Mar-Apr;55(2):25-8.
It has been found that injection of dalargin before the occlusion of the left anterior coronary artery prevents an increase of cAMP content in the myocardium and blood plasma. In the myocardium of rats given dalargin before acute myocardial ischemia, the content of cGMP was increased and the level of somatostatin was reduced. It is assumed that the increase of the content of cGMP and the reduction of cAMP and somatostatin levels in the myocardium play an important role in antiarrhythmic action of dalargin.
已经发现，在左冠状动脉前降支闭塞前注射达乐argin可防止心肌和血浆中cAMP含量增加。在急性心肌缺血前给予达乐argin的大鼠心肌中，cGMP含量增加，生长抑素水平降低。据推测，心肌中cGMP含量的增加以及cAMP和生长抑素水平的降低在达乐argin的抗心律失常作用中起重要作用。
