Maslov L N, Lishmanov Y B
Tomsk Research Centre of the Russian Academy of Medical Sciences, Russian Federation.
Int J Cardiol. 1993 Jul 1;40(2):89-94. doi: 10.1016/0167-5273(93)90269-m.
We studied antiarrhythmic action of D-Ala 2, Leu 5, Arg 6-enkephalin (dalargin) in experiments on male rats. Dalargin is reported to prevent heart rhythm disturbance and heart electrical stability decrease in experimental coronary occlusion, postinfarction, cardiosclerosis and emotional stress. Dalargin prevents acute myocardial ischaemia-induced increase of cAMP content in blood serum and cardiac muscle, as an indirect feature of its antiadrenergic activity. D-Ala 2, Leu 5, Arg 6-enkephalin leads to a decrease of cAMP content in myocardium and blood plasma, which presumably indicates a decrease of sympathetic tone. The data strongly suggest that cGMP content increase and somatostatin level decrease in cardiac muscle play a significant role in antiarrhythmic action of dalargin.
我们在雄性大鼠实验中研究了D-丙氨酸2、亮氨酸5、精氨酸6-脑啡肽（达立麻）的抗心律失常作用。据报道，达立麻可预防实验性冠状动脉闭塞、心肌梗死后、心脏硬化和情绪应激时的心律紊乱及心脏电稳定性降低。达立麻可预防急性心肌缺血引起的血清和心肌中cAMP含量增加，这是其抗肾上腺素能活性的一个间接特征。D-丙氨酸2、亮氨酸5、精氨酸6-脑啡肽可导致心肌和血浆中cAMP含量降低，这可能表明交感神经张力降低。数据强烈表明，心肌中cGMP含量增加和生长抑素水平降低在达立麻的抗心律失常作用中起重要作用。
