Håkansson H O, Ohlsson K
Department of Surgical Pathophysiology, University of Lund, Malmö General Hospital, Sweden.
Gastroenterol Jpn. 1992 Oct;27(5):652-6. doi: 10.1007/BF02774981.
Pancreatic elastase-induced degradation of some plasma proteins was studied in an in vitro model. The digestion was correlated with the degree of saturation of the alpha 1-proteinase inhibitor (alpha 1PI) and also with varying amounts of secretory leucocyte proteinase inhibitor (SLPI). SLPI was found to inhibit pancreatic elastase showing a Ki of about 10(-7) M for the complex. On the addition of human pancreatic elastase to plasma cleavage of C3, kininogen, fibrinogen and fibronectin was observed when the alpha 1PI approached saturation. In the present in vitro model it was possible to block the cleavage of the four plasma proteins, mentioned above completely with SLPI. Addition of the inhibitor also decreased the consumption of alpha 1PI.
在体外模型中研究了胰腺弹性蛋白酶诱导的某些血浆蛋白降解。消化作用与α1-蛋白酶抑制剂（α1PI）的饱和程度以及不同量的分泌型白细胞蛋白酶抑制剂（SLPI）相关。发现SLPI可抑制胰腺弹性蛋白酶，该复合物的抑制常数（Ki）约为10^(-7) M。当向血浆中加入人胰腺弹性蛋白酶时，当α1PI接近饱和时，观察到C3、激肽原、纤维蛋白原和纤连蛋白的裂解。在当前的体外模型中，用SLPI可以完全阻断上述四种血浆蛋白的裂解。加入该抑制剂还减少了α1PI的消耗。
