Porrini A M, Gambi D, Malatesta G
Department of Clinical Neurology, University of Chieti, Italy.
J Neurol. 1992 Oct;239(8):437-40. doi: 10.1007/BF00856808.
Helper-inducer (CD29+CD4+) and suppressor-inducer (CD45RACD4+) T-cells have been recently renamed as memory and naive T-cells, respectively. We measured cells expressing these phenotypes in peripheral blood of 46 definite multiple sclerosis (MS) patients [32 relapsing-remitting (RR-MS), 14 secondary progressive (P-MS)] and controls. CD25+ (interleukin-2-receptor-positive) cells were also evaluated in the same groups of patients. RR-MS patients showed increased levels of CD29+CD4+ and CD25+ cells compared with controls. This finding was more evident in RR-MS patients during the attack than during the stable phase of the disease. In P-MS patients we found a reduction of CD45+CD4+ cells compared with either RR-MS patients or control subjects. Our results show that RR-MS and P-MS are characterized by two different T-cell subpopulations. This finding supports the hypothesis that during the evolution from RR-MS and P-MS changes occur in the immunological status of the patients.
辅助诱导型（CD29+CD4+）和抑制诱导型（CD45RACD4+）T细胞最近分别被重新命名为记忆性T细胞和初始T细胞。我们检测了46例明确的多发性硬化症（MS）患者[32例复发缓解型（RR-MS），14例继发进展型（P-MS）]和对照组外周血中表达这些表型的细胞。在同一组患者中也评估了CD25+（白细胞介素-2受体阳性）细胞。与对照组相比，RR-MS患者的CD29+CD4+和CD25+细胞水平升高。这一发现在RR-MS患者发作期间比疾病稳定期更为明显。与RR-MS患者或对照组相比，我们发现P-MS患者的CD45+CD4+细胞减少。我们的结果表明，RR-MS和P-MS具有两种不同的T细胞亚群特征。这一发现支持了这样的假设，即在从RR-MS到P-MS的演变过程中，患者的免疫状态会发生变化。
