Macor S, Porrini A M, Giampietro A, Malatesta G, Gambi D
Department of Clinical Neurology, University of Chieti, Italy.
Acta Neurol (Napoli). 1991 Dec;13(6):590-6.
Two-color flow-cytometric analysis on peripheral blood lymphocytes of 46 untreated multiple sclerosis patients (MS), 36 other medical disease patients (OMD) and 19 healthy control subjects (HC) was performed to know the relationships between T and B cell subpopulations. In MS patients we observed an increase of total lymphocyte count and an increase of CD4+CD29+ cells, which are adjuvant to B cell in antibody production. We hypothesized this change is related to the reduction of CD21+ cells, expressing B2 antigen which disappears after B cell activation. The unperfect balance of immune system in MS was also demonstrated by the increased level of CD25+ cells in relapsing-remitting patients and by the decreased level of CD4+ CD45RA+ (suppressor inducer) cells in progressive patients.
对46例未经治疗的多发性硬化症患者（MS）、36例其他内科疾病患者（OMD）和19名健康对照者（HC）的外周血淋巴细胞进行双色流式细胞术分析，以了解T细胞和B细胞亚群之间的关系。在MS患者中，我们观察到总淋巴细胞计数增加以及CD4+CD29+细胞增加，这些细胞在抗体产生中辅助B细胞。我们推测这种变化与CD21+细胞减少有关，CD21+细胞表达B2抗原，在B细胞活化后消失。复发缓解型患者CD25+细胞水平升高以及进展型患者CD4+CD45RA+（抑制诱导）细胞水平降低也证明了MS患者免疫系统的不平衡。
