Cañete J D, Sanmartí R, Collado A, Ercilla G, Armengol P, Vendrell J, Gratacós J, Muñoz-Gomez J
Department of Rheumatology, Hospital Clínic i Provincial de Barcelona, Spain.
Br J Rheumatol. 1992 Nov;31(11):743-6. doi: 10.1093/rheumatology/31.11.743.
Several studies of DNA restriction fragment length polymorphism (RFLP) in ankylosing spondylitis (AS) have been carried out. The association between a recently identified class I HLA 9.2 kb PvuII RFLP and AS remain controversial. In order to evaluate this possible association in an Euro-Caucasian population, the genomic DNA of 42 AS patients and 18 patients with Reiter's syndrome (RS) and 42 healthy controls was analysed. Non-association between 9.2 kb PvuII RFLP and AS or RS was observed. As described previously, a strong association between this fragment and HLA-A3 and/or HLA-A9 antigens was demonstrated. A study of two families showed that this RFLP segregates with HLA-A3 and/or HLA-A9 and independently of the HLA-B27. Our findings support the view that the 9.2 kb PvuII fragment is not universally associated with AS.
