PAF formation by human gastrointestinal mucosa/submucosa in-vitro: release by ricinoleic acid, and inhibition by 5-aminosalicylic acid.

作者信息

Capasso F, Tavares I A, Bennett A

机构信息

Department of Surgery, King's College School of Medicine and Dentistry, Rayne Institute, London, UK.

出版信息

J Pharm Pharmacol. 1992 Sep;44(9):771-2. doi: 10.1111/j.2042-7158.1992.tb05518.x.

Human isolated gastrointestinal mucosa/submucosa incubated with ricinoleic acid (12.5-100 micrograms mL-1) or the calcium ionophore A23187 (10 micrograms mL-1) released platelet-activating factor (PAF) as determined by a scintillation proximity assay after extraction and purification. 5-Aminosalicylic acid (25-100 micrograms mL-1) inhibited PAF release by ricinoleic acid in a concentration-dependent manner, and 50 micrograms mL-1 reduced the effect of A23187. We suggest that PAF may play a role in the laxation and mucosal damage by ricinoleic acid released from castor oil.